منابع مشابه
Cannabinoid receptors
What are endocannabinoids? THC and WIN are examples of exogenous cannabinoid receptor ligands, but the body makes its own ligands, too, and these are referred to as endocannabinoids. Two of the best-characterized endocannabinoids are anandamide and 2-arachidonylglycerol (2AG). Other candidate endocannabinoids have been identified but which, if any, of these compounds are physiologically relevan...
متن کامل“The Cannabinoid Receptors”
As research has progressed, the cannabinoid CB1 and CB2 receptors have expanded significantly in importance within the neuroscience mainstream. In the presented book leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid ...
متن کاملCannabinoid receptors and pain
Activation of both cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors reduces nociceptive processing in acute and chronic animal models of pain. In addition, nociceptive processing is tonically modulated by endogenous cannabinoids (endocannabinoids, ECs). This review examines the role of cannabinoids and ECs in the brain stem–spinal pathway of pain inhibition. Preclinical studies evaluating ...
متن کاملCannabinoid Receptors Modulators
AM 251 ALX-270-239-M001 1 mg ALX-270-239-M005 5 mg Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A. Binds with high affinity to cannabinoid receptor CB1 (Ki=7.49nM; 306-fold selective over CB2 receptors). LIT: Binding of the non-classical cannabinoid CP 55, 940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors: S.J. Gatley, et al.; Life Sci. 61, PL ...
متن کاملCannabinoid CB1 Receptors Mediate the Gastroprotective Effect of Neurotensin
Objective(s) Several lines of evidence indicate that neuropeptides exhibit protective properties against gastroduodenal ulcers. Neurotensin, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. In the present study, we aimed to investigate the gastroprotective potential of either p...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2002
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)01203-4